(+)JQ1 is a member of the triazolo-diazepine compound family, which functions as a potent, specific, and reversible pan-BET (bromodomain and extra-terminal motif) family inhibitor. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of about 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. Please contact us for GMP-grade inquiries.
Products > PROTAC, Molecular glue > Inhibitors
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