Fludarabine is a purine nucleoside derivative that disrupts ribonucleotide reductase and DNA polymerase in blood cells. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP, and survivin expression. Fludarabine displays anticancer activity against human hematological malignancies in vivo. Please contact us for GMP-grade inquiries.
Products > Nucleoside, Nucleotide, Phosphoramidite > Nucleosides | Products > Nucleoside, Nucleotide, Phosphoramidite > Nucleosides > Fluoro-Modified Nucleosides
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