244cis (solution in ethanol)

Overview

244cis is an ionizable cationic lipid (pKa = 6.3) utilized in the development of lipid nanoparticles (LNPs). In mice, LNPs containing 244cis and an mRNA reporter preferentially accumulate in the lungs and result in lower serum chemokine (C-C motif) ligand 2 (Ccl2) levels compared to LNPs with SM-102. Intravenous administration of 244cis-based LNPs encapsulating mRNA encoding Cre recombinase increases tdTomato fluorescence in lung endothelial, epithelial, and immune cells, as well as fibroblasts, in mice engineered with a floxed STOP codon to prevent tdTomato expression. Furthermore, LNPs with 244cis and siRNA targeting G2 and S-phase expressed 1 (Gtse1) reduce hepatic fibrosis, decrease Il-6 and Tnf-α production, and lower alanine transaminase (ALT) and aspartate aminotransferase (AST) levels compared to SM-102-based LNPs in a mouse model of carbon tetrachloride-induced liver injury.

Application

PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Ionizable Lipid | PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Branched Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Ionizable Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Branched Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid > Multi chargeable lipid | Products > Lipids In Drug Delivery > Branched Lipid > Branched Lipid

Product Information

• Catalog No.: BP-42716
• CAS No.: 2956402-64-3
• Molecular Formula: C60H111N3O6
• Molecular Weight: 970.6
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source