MG-277 is a molecular glue degrader that targets the translation termination factor GSPT1 via the Cereblon E3 ligase pathway. This compound effectively facilitates the degradation of GSPT1 and demonstrates significant inhibition of tumor cell growth in a p53-independent manner. Its structural features enable potent interactions with cellular components, contributing to its effectiveness in research settings focused on cellular regulation and potential therapeutic applications. Reagent-grade; for laboratory research purposes only.
Products > PROTAC, Molecular glue > Degraders
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