AU-15330 is a PROTAC degrader targeting the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. This compound effectively inhibits tumor growth in prostate cancer xenograft models and enhances the efficacy of the AR antagonist enzalutamide. Additionally, AU-15330 demonstrates the ability to induce remission in models of castration-resistant prostate cancer while maintaining a favorable safety profile. Reagent-grade; for laboratory research purposes only.
Products > PROTAC, Molecular glue > Degraders
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