L-threo-sphingosine (d18:1)

Overview

L-threo-sphingosine (d18:1), an analog of D-erythro-sphingosine, inhibits protein kinase C with 50% inhibition at 2.2 mol%, making it slightly more potent than D-erythro-sphingosine (50% inhibition at 2.8 mol%) and other analogs with shorter alkyl chains. Unlike D-erythro-sphingosine, L-threo-Sphingosine C-18 does not reduce serine palmitoyltransferase (SPT) activity, the rate-limiting enzyme in ceramide biosynthesis, in primary cultured cerebellar cells.

Application

Products > Lipids In Drug Delivery > Sphingolipids | Products > Lipids In Drug Delivery > Sphingolipids > Sphingosine

Product Information

• Catalog No.: BP-42457
• CAS No.: 25695-95-8
• Molecular Formula: C18H37NO2
• Molecular Weight: 299.5
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source