Safingol is the L-threo diastereomer of D-erythro-sphinganine and a dual inhibitor of PKC and sphingosine kinase (SPHK). It inhibits PKC by binding to the regulatory phorbol-binding domain (IC50 = 24 µM) and also inhibits SPHK (Ki ≈ 5 µM).
Products > Lipids In Drug Delivery > Sphingolipids | Products > Lipids In Drug Delivery > Sphingolipids > Sphinganine
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