SIAIS178 represents an innovative proteolysis-targeting chimeric (PROTAC) degrader—a unique hybrid molecule intertwining the BCR-ABL kinase inhibitor dasatinib with a ligand designed for the Von Hippel-Lindau (VHL) E3 ubiquitin ligase through an optimized linker. It effectively directs the BCR-ABL protein for degradation through VHL-mediated mechanisms. Reagent-grade; for laboratory research purposes only.
Products > PROTAC, Molecular glue > Degraders
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