TCO-PEG4-TFP Ester

Overview

TCO-PEG4-TFP Ester is an amine-reactive labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. A 2,3,5,6-tetrafluorophenol (TFP) is a reactive ester that displays much better stability toward hydrolysis in aqueous media resulting in more efficiency and better reproducible labeling of biopolymers. TFP ester of carboxylic acids react with primary amines at the same rate as NHS ester forming covalent amide bond that is identical to one formed by the reaction between primary amines and NHS esters or sulfo-NHS esters. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.

Application

PEGylation of Protein, Peptide & Oligo > Click Chemistry Reactive > TCO-PEG | Antibody Drug Conjugates > Click Chemistry Reactive > TCO-PEG | Drug Delivery, Surface Modification > Click Chemistry Reactive > TCO-PEG | Products > PEG Linkers > TCO-PEG | Products > PEG Linkers > TCO-PEG > TCO-PEG-TFP ester | Products > Click Chemistry Reagents > TCO > Amine Reactive

Product Information

• Catalog No.: BP-40298
• CAS No.: 2268817-73-6
• Molecular Formula: C26H35F4NO8
• Molecular Weight: 565.6
• Storage: -20°C
• Solubility: DMSO, DMF, THF, Acetonitrile, DCM
• Availability: In Stock

Source

Original product source