D-Lin-MC3-DMA (MC3) is a potent ionizable lipid used in lipid nanoparticle (LNP) formulations for delivering siRNA, mRNA, and DNA in gene therapy and RNA-based therapies. With a pKa of 6.44 , it facilitates endosomal escape by becoming protonated in acidic environments, making it ideal for intracellular delivery . MC3 is a key component in mRNA vaccines and non-viral gene delivery systems, available in reagent grade for research purposes.
Drug Formulation > Lipids for Drug Delivery > Ionizable Lipid
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