Product

TRIETHYL 4-PHOSPHONOCROTONATE

CAS No.：10236-14-3

Other grades of this product :

TRIETHYL 4-PHOSPHONOCROTONATE Basic information

Product Name:	TRIETHYL 4-PHOSPHONOCROTONATE
Synonyms:	4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER;TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE;TRIETHYL 4-PHOSPHONO-2-BUTENOATE;TRIETHYL 4-PHOSPHONOCROTONATE;TRIETHYL 4-PHOSPHONOCROTONATE, TECH., 90 %, MIXTURE OF ISOMERS;Triethyl 4-phosphonocrotonate, predominantly trans, 92%;triethyl 4-phosphonocrotonate, cis + trans;triethyl 4-phosphonocrotonate, mixture of isomers
CAS:	10236-14-3
MF:	C10H19O5P
MW:	250.23
EINECS:
Product Categories:	C-C Bond Formation;Horner-Wadsworth-Emmons Reagents;Olefination
Mol File:	10236-14-3.mol

TRIETHYL 4-PHOSPHONOCROTONATE Chemical Properties

Boiling point	135 °C0.4 mm Hg(lit.)
density	1.128 g/mL at 25 °C(lit.)
refractive index	n20/D 1.455(lit.)
Fp	>230 °F
form	Liquid
color	Clear light yellow
CAS DataBase Reference	10236-14-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39-24/25
WGK Germany	3
HazardClass	IRRITANT
HS Code	29319090

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

TRIETHYL 4-PHOSPHONOCROTONATE Usage And Synthesis

Chemical Properties	CLEAR LIGHT YELLOW LIQUID
Uses	Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
Uses	Reactant for: Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions Orally bioavailable GPR40 agonist synthesis Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2 Preaparation of mGlu4R agonists Dearomatizing cyclization of nicotinyl-substituted esters and ketones

TRIETHYL 4-PHOSPHONOCROTONATE Preparation Products And Raw materials

Raw materials

DIETHYL VINYLPHOSPHONATE-->ethyl 4-bromocrotonate-->Triethyl phosphite-->Ethyl diazoacetate

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