TRIETHYL 4-PHOSPHONOCROTONATE

CAS No.：10236-14-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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TRIETHYL 4-PHOSPHONOCROTONATE Basic information

Product Name:	TRIETHYL 4-PHOSPHONOCROTONATE
Synonyms:	4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER;TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE;TRIETHYL 4-PHOSPHONO-2-BUTENOATE;TRIETHYL 4-PHOSPHONOCROTONATE;TRIETHYL 4-PHOSPHONOCROTONATE, TECH., 90 %, MIXTURE OF ISOMERS;Triethyl 4-phosphonocrotonate, predominantly trans, 92%;triethyl 4-phosphonocrotonate, cis + trans;triethyl 4-phosphonocrotonate, mixture of isomers
CAS:	10236-14-3
MF:	C10H19O5P
MW:	250.23
EINECS:
Product Categories:	C-C Bond Formation;Horner-Wadsworth-Emmons Reagents;Olefination
Mol File:	10236-14-3.mol

TRIETHYL 4-PHOSPHONOCROTONATE Chemical Properties

Boiling point	135 °C0.4 mm Hg(lit.)
density	1.128 g/mL at 25 °C(lit.)
refractive index	n20/D 1.455(lit.)
Fp	>230 °F
form	Liquid
color	Clear light yellow
CAS DataBase Reference	10236-14-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39-24/25
WGK Germany	3
HazardClass	IRRITANT
HS Code	29319090

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

TRIETHYL 4-PHOSPHONOCROTONATE Usage And Synthesis

Chemical Properties	CLEAR LIGHT YELLOW LIQUID
Uses	Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
Uses	Reactant for: Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions Orally bioavailable GPR40 agonist synthesis Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2 Preaparation of mGlu4R agonists Dearomatizing cyclization of nicotinyl-substituted esters and ketones

TRIETHYL 4-PHOSPHONOCROTONATE Preparation Products And Raw materials

Raw materials

DIETHYL VINYLPHOSPHONATE-->ethyl 4-bromocrotonate-->Triethyl phosphite-->Ethyl diazoacetate

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