Product

Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

CAS No.：645400-44-8

Other grades of this product :

Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI) Basic information

Product Name:	Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)
Synonyms:	Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI);tert-butyl ((1S,3S)-3-aminocyclopentyl)carbamate;Carbamic acid, N-[(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester;tert-butyl N-[(1S,3S)-3-aminocyclopentyl]carbamate;[(1S,3S)-3-Amino-1-(boc-amino)cyclopentane;TERT-BUTYL ((IS, 3S)-3- AMINOCYCLOPENTYL)CARBAMATE
CAS:	645400-44-8
MF:	C10H20N2O2
MW:	200.28
EINECS:
Product Categories:	N-BOC;CYCLOPENTANE
Mol File:	645400-44-8.mol

Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties

Boiling point	304.2±31.0 °C(Predicted)
density	1.04±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	12.37±0.40(Predicted)

Safety Information

HS Code

2924297099

MSDS Information

Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis

Uses

tert-butyl N-[(1S,3S)-3-aminocyclopentyl]carbamate is used as a reactant in the synthesis of C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 inhibitors.

Synthesis

A flask containing tert-butyl [(1S,3S)-3-aminocyclopentyl]carbamate (16.5 g, crude ~0.05 mol) and 1.7 g Pd-C (10% paste) in MeOH (300 mL) was exposed to a positive pressure of hydrogen gas (balloon) over weekend. The catalyst was filtered off and the mixture was concentrated to afford the title compound (9.5 g) as a thick colorless viscous oil. Tert-butyl [(1S,3S)-3-aminocyclopentyl]carbamate, Yield (9.5 g)

Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials

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