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| 2,2-DIMETHYLTHIOPROPIONAMIDE Basic information |
| Product Name: | 2,2-DIMETHYLTHIOPROPIONAMIDE | | Synonyms: | 2,2,2-Dimethylthiopropionamide;2,2-DIMETHYLTHIOPROPIONAMIDE;2,2,2-Trimethylthioacetamide,;Neopentanethioamide;NSC 381432;Thiopivalamide;2,2-DIMETHYLTHIOPROPIOMIDE;Propanethioamide, 2,2-dimethyl- | | CAS: | 630-22-8 | | MF: | C5H11NS | | MW: | 117.21 | | EINECS: | 677-829-5 | | Product Categories: | | Mol File: | 630-22-8.mol |
| 2,2-DIMETHYLTHIOPROPIONAMIDE Chemical Properties |
| Melting point | 117-119℃ (ethyl acetate hexane ) | | Boiling point | 162.1±23.0℃ (760 Torr) | | density | 0.978±0.06 g/cm3 (20 ºC 760 Torr) | | Fp | 51.9±22.6℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform, Ethyl Acetate | | form | Solid | | pka | 13.33±0.29(Predicted) | | color | White | | Water Solubility | Soluble in water (10 g/L) (25°C). |
| 2,2-DIMETHYLTHIOPROPIONAMIDE Usage And Synthesis |
| Uses | 2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents). |
| 2,2-DIMETHYLTHIOPROPIONAMIDE Preparation Products And Raw materials |
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