1-CHLORO-4-IODOBUTANE

CAS No.：10297-05-9

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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1-CHLORO-4-IODOBUTANE Basic information

Product Name:	1-CHLORO-4-IODOBUTANE
Synonyms:	1-chloro-4-iodo-butan;Butane, 1-chloro-4-iodo-;TETRAMETHYLENE CHLOROIODIDE;1-CHLORO-4-IODOBUTANE;1-IODO-4-CHLOROBUTANE;4-Chlorobutyl iodide;1-Chloro-4-iodobutane (stabilized with Copper chip);4-Iodobutyl chloride, 4-Chlorobutyl iodide
CAS:	10297-05-9
MF:	C4H8ClI
MW:	218.46
EINECS:	233-669-4
Product Categories:	Organic Building Blocks;Alkyl;Halogenated Hydrocarbons
Mol File:	10297-05-9.mol

1-CHLORO-4-IODOBUTANE Chemical Properties

Melting point	93 °C
Boiling point	88-89 °C/19 mmHg (lit.)
density	1.785 g/mL at 25 °C (lit.)
refractive index	n20/D 1.54(lit.)
Fp	200 °F
storage temp.	2-8°C(protect from light)
solubility	Chloroform, Ethyl Acetate
form	Oil
color	Clear Colourless
Specific Gravity	1.785
Sensitive	Light Sensitive
BRN	1361365
CAS DataBase Reference	10297-05-9(CAS DataBase Reference)
EPA Substance Registry System	Butane, 1-chloro-4-iodo- (10297-05-9)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
TSCA	Yes
HS Code	29031980

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

1-CHLORO-4-IODOBUTANE Usage And Synthesis

Chemical Properties	clear yellow to brown liquid
Uses	1-Chloro-4-iodobutane acts as a reagent in the synthesis of alkyl chromones/quinolones via cyclization/alkylation of enaminones and as an intermediate in many pharmaceutical synthesis.
Uses	1-Chloro-4-iodobutane may be used in the following studies: Preparation of 6-hendecenoic acid. Catalytic asymmetric synthesis of levobupivacaine. Synthesis of alkaloids such as deoxyvasicinone, mackinazolinone.
General Description	1-Chloro-4-iodobutane is a halogenated hydrocarbon. It is an α,ω-dihaloalkane and undergoes electrogenerated Nickel(I) salen (N,N′-bis(salicylidene)ethylenediamine) catalyzed reduction to afford 1,8-dichlorooctane. Electrochemical reduction of 1-chloro-4-iodobutane at glassy carbon cathode has been investigated by cyclic voltammetry and controlled-potential electrolysis.

1-CHLORO-4-IODOBUTANE Preparation Products And Raw materials

Preparation Products

4-(4-CHLOROBUTYL) PYRIDINE-->1-CHLORO-4-PHENYLBUTANE-->Biphenyl

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