Abacavir Carboxylate

CAS No.：384380-52-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Abacavir Carboxylate Basic information

Product Name:	Abacavir Carboxylate
Synonyms:	Abacavir Carboxylate;(1S,4R)-4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-carboxylic Acid;2269W;(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-ene-1-carboxylic acid;(1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enecarboxylic acid;2-Cyclopentene-1-carboxylic acid, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-;Abacavir Impurity 14
CAS:	384380-52-3
MF:	C14H16N6O2
MW:	300.32
EINECS:
Product Categories:	Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;Bases & Related Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Nucleotides;Pharmaceuticals
Mol File:	384380-52-3.mol

Abacavir Carboxylate Chemical Properties

Melting point	208-210°C (dec.)
storage temp.	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility	DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form	Solid
color	Off-White to Pale Beige
Stability:	Hygroscopic

Safety Information

MSDS Information

Abacavir Carboxylate Usage And Synthesis

Description	Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.
Chemical Properties	Off-White Solid
Uses	A major metabolite of Abacavir
Uses	Abacavir Carboxylate (Abacavir - In House Impurity) is a major metabolite of Abacavir (A105000) in human urine and cerebrospinal fluid (1,2,3).

Abacavir Carboxylate Preparation Products And Raw materials

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