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| Pyroxamide Basic information |
| Product Name: | Pyroxamide | | Synonyms: | 382180-17-8; NSC-696085; N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE; N-HYDROXY-N'-(PYRIDIN-3-YL)OCTANEDIAMIDE; NSC696085; NSC 696085;n-hydroxy-n'-(pyridin-3-yl)octanediamide;NSC 696085;Pyroxamide 2-[1-carbaMoyl-N-(2H-pyran-2-yl)forMaMido]-N-hydroxy-N'-(pyridin-3-yl)octanediaMide;PyroxaMide (NSC 696085);N1-Hydroxy-N8-3-pyridinyl-octanediamide;N1-Hydroxy-N8-(pyridin-3-yl)octanediamide | | CAS: | 382180-17-8 | | MF: | C13H19N3O3 | | MW: | 265.31 | | EINECS: | | Product Categories: | | Mol File: | 382180-17-8.mol |
| Pyroxamide Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble10mg/mL (clear solution) | | form | powder | | color | white to beige |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| Pyroxamide Usage And Synthesis |
| Description | Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture. | | Uses | Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes imp
licated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells
in vitro and in vivo. Induces p21/WAF1 expression in tumor cells. | | Uses | Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture. | | Uses | Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells. | | references | [1]. butler lm, webb y, agus db, et al. inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. clin cancer res, 2001, 7(4): 962-970.[2]. kutko mc, glick rd, butler lm, et al. histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. clin cancer res, 2003, 9(15): 5749-5755. |
| Pyroxamide Preparation Products And Raw materials |
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