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| TYRPHOSTIN A9 Basic information |
| Product Name: | TYRPHOSTIN A9 | | Synonyms: | ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)CINNAMONITRILE;TYRPHOSTIN A9 \ SELECTIVE PDGF TYROSINE;TYRPHOSTIN A9 99+%;Malonobene;2-(3,5-di-tert-butyl-4-hydroxybenzylidene)Malononitrile;Tyrphostin 9 (SF 6847);Propanedinitrile, 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-;[[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]METHYLENE]-PROPANEDINITRILE | | CAS: | 10537-47-0 | | MF: | C18H22N2O | | MW: | 282.38 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 10537-47-0.mol |
| TYRPHOSTIN A9 Chemical Properties |
| Melting point | 141-143℃ (ethanol ) | | Boiling point | 424.99°C (rough estimate) | | density | 1.0741 (rough estimate) | | refractive index | 1.5700 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | ethanol: 20 mg/mL | | form | solid | | pka | 7.55±0.40(Predicted) | | color | yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | CAS DataBase Reference | 10537-47-0(CAS DataBase Reference) | | EPA Substance Registry System | Malonoben (10537-47-0) |
| Hazard Codes | T | | Risk Statements | 23/24/25 | | Safety Statements | 36/37/39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | OO3737000 | | HazardClass | 6.1 |
| TYRPHOSTIN A9 Usage And Synthesis |
| Description | Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4 | | Uses | Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells. | | Uses | SF 6847 is an inhibitor of EGFR with IC50 of 460 μM. | | Uses | Selective inhibitor of PDGF receptor tyrosine kinase | | General Description | A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines. | | Biological Activity | Potent uncoupler of oxidative phosphorylation. | | Biochem/physiol Actions | Cell permeable: yes | | References | 1) Bilder?et al. (1991),?Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells; Am. J. Physiol.,?260?C721
2) Terada?et al. (1981),?The interaction of highly active uncouplers with mitochondria; Biochim. Biophys. Acta,?639?225
3) Burger?et al. (1995),?Tyrphostin AG17, [3,5-Ditert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria; Cancer Res.,?55?2794
4) Thyberg?et al. (1998),?Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells; Eur. J. Cell Biol.,?76?33 |
| TYRPHOSTIN A9 Preparation Products And Raw materials |
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