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| Isoquinolin-4-ol Basic information |
| Isoquinolin-4-ol Chemical Properties |
| Melting point | 223-225℃ | | Boiling point | 425.4±18.0 °C(Predicted) | | density | 1.26 | | storage temp. | Sealed in dry,Room Temperature | | solubility | Deuterated Chloroform, Dichloromethane, Ehtyl Acetate | | form | Solid | | pka | 5.25±0.40(Predicted) | | color | Off White |
| Hazard Codes | Xn | | Risk Statements | 22 | | HS Code | 2933499090 |
| Isoquinolin-4-ol Usage And Synthesis |
| Uses | 4-?Isoquinolinol is a metabolite of Isoquinoline (I874930) and has a high anti-radical, hypnotic-sedative and myorelaxant activities. 4-?Isoquinolinol is also an impurity of 1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride (P309050), which is a useful synthetic intermediate in the synthesis of cis-Hydroxy Solifenacin (H953525) and cis-Hydroxy Solifenacin N-Oxide (H953485); both metabolites of Solifenacin (S676700, HCl) which is a muscarinic M3 receptor antagonist and is used in treatment of urinary incontinence. | | Synthesis Reference(s) | Journal of the American Chemical Society, 69, p. 1946, 1947 DOI: 10.1021/ja01200a032 |
| Isoquinolin-4-ol Preparation Products And Raw materials |
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