Other grades of this product :
| Product Name: | THPN | | Synonyms: | 1-(3,4,5-Trihydroxyphenyl)-1-nonanone;THPN;1-Nonanone, 1-(3,4,5-trihydroxyphenyl)-;THPN >=98% (HPLC) | | CAS: | 100079-26-3 | | MF: | C15H22O4 | | MW: | 266.33 | | EINECS: | | Product Categories: | | Mol File: | 100079-26-3.mol |
| storage temp. | 2-8°C | | form | powder | | color | white to beige |
| Uses | THPN is a Nur77 agonist. THPN binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines. | | General Description | THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B. | | Biochem/physiol Actions | THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model. |
| THPN Preparation Products And Raw materials |
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