THPN

CAS No.：100079-26-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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THPN Basic information

Product Name:	THPN
Synonyms:	1-(3,4,5-Trihydroxyphenyl)-1-nonanone;THPN;1-Nonanone, 1-(3,4,5-trihydroxyphenyl)-;THPN >=98% (HPLC)
CAS:	100079-26-3
MF:	C15H22O4
MW:	266.33
EINECS:
Product Categories:
Mol File:	100079-26-3.mol

THPN Chemical Properties

storage temp.	2-8°C
form	powder
color	white to beige

Safety Information

MSDS Information

THPN Usage And Synthesis

Uses	THPN is a Nur77 agonist. THPN binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.
General Description	THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B.
Biochem/physiol Actions	THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model.

THPN Preparation Products And Raw materials

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