PHE-ARG BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE

CAS No.：100929-99-5

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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PHE-ARG BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE Basic information

Product Name:	PHE-ARG BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE
Synonyms:	H-PHE-ARG-BETANA 2 HCL;PHE-ARG BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE;phe-arg B-naphthylamide dihydrochloride;phe-argbeta-naphthylamide2HCl;phe-arg β-naphthylamide dihydrochloride;H-Phe-Arg-bNA·2HCl;110 dihydrochloride;MC-207
CAS:	100929-99-5
MF:	C25H32Cl2N6O2
MW:	519.47
EINECS:
Product Categories:	Activity;AlphabeticalEnzyme Substrates;Fluorescent Enzyme Substrates;Fluorescent Probes, Labels, Particles and Stains;Fluorogenic
Mol File:	100929-99-5.mol

PHE-ARG BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE Chemical Properties

Melting point	>250o C
storage temp.	-20°C
solubility	Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

PHE-ARG BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE Usage And Synthesis

Chemical Properties	White powder
Uses	Substrate for dipeptidyl aminopeptidase I (cathepsin C).
Uses	Phe-Arg-beta-naphthylamide Dihydrochloride can be used as a reagent in organic synthesis.
Uses	Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.
General Description	Phe-Arg β-naphthylamide, a peptidomimetic compound, is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.

PHE-ARG BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE Preparation Products And Raw materials

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