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| 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Basic information |
| Product Name: | 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE | | Synonyms: | 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE;2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride;(2R,3R,4R)-3,4-Dihydroxy-2-(hydroxymethyl)pyrrolidine hydrochloride;3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, hydrochloride, (2R,3R,4R)-;1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride enzyme inhibitor | | CAS: | 100991-92-2 | | MF: | C5H12ClNO3 | | MW: | 169.61 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Chemical Properties |
| Melting point | 110-112 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1)) | | storage temp. | 2-8°C |
| 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Usage And Synthesis |
| Description | 1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC50 = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC50s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models. | | Uses | 1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor. | | General Description | 1,4-Dideoxy-1,4-imino-D-arabinitol is a naturally occurring pyrrolidine alkaloid. It is found in Arachniodes standishii and Angylocalyx boutiqueanus. | | Biochem/physiol Actions | Inhibitor of glycogen phosphorylase and α-glucosidases. |
| 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Preparation Products And Raw materials |
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