| MICROCYSTIN YR Basic information |
| Product Name: | MICROCYSTIN YR |
| Synonyms: | MICROCYSTIN YR;microcystin yr from microcystis aeruginosa;MICROCYSTIN-YR SOLUTION;Cyanoginosin la, 3-L-tyrosine-5-L-arginine;Cyanoginosin la, 3-L-tyrosyl-5-L-arginine;Cyanoginosin la, 3-tyrosyl-5-arginine-;Cyanoginosin yr;Cyanoginosin-yr |
| CAS: | 101064-48-6 |
| MF: | C52H72N10O13 |
| MW: | 1045.19 |
| EINECS: | 621-458-3 |
| Product Categories: | Cyanobacterial ToxinsTyrosine Phosphatase Biology;Protein Phosphatase 2 (PP2);Tyrosine Phosphatase Inhibitors;Application Index;Cell Signaling Enzymes;Natural Products |
| Mol File: | 101064-48-6.mol |
| MICROCYSTIN YR Chemical Properties |
| density | 1.33±0.1 g/cm3(Predicted) |
| Fp | 11 °C |
| storage temp. | −20°C |
| solubility | methanol: 2 mg/mL (further dilute to 10% (v/v) methanol) |
| pka | 3.02±0.70(Predicted) |
| form | white powder |
| EPA Substance Registry System | Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-tyrosyl-(3S)-3-methyl-D-.beta.-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-.gamma.-glutamyl] (101064-48-6) |
| Safety Information |
| Hazard Codes | T+,T,F |
| Risk Statements | 26/27/28-36/37/38-43-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36/37/39-45-36/37-16-7 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | 000000030272 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| MICROCYSTIN YR Usage And Synthesis |
| Uses | Microcystin YR from Microcystis aeruginosa has been used to assess cytotoxicity in neutrophils using DNA fragmentation and cell viability assays and as a reference standard in the quantification of microcystin from water samples. |
| General Description | Microcystin is a potent cyanotoxin produced by the bloom of Microcystis aeruginosa. It is harmful to aquatic animals. It is a heptapeptide and exists as multiple variant forms. pCO2 and nitrogen levels modulate the toxic variants levels. It elicits damage to the liver and other organs. |
| Biochem/physiol Actions | Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1. Toxicity to undifferentiated cells was seen by inhibition of neutral red uptake, >80% at 100 μM, after 48 h. |
| MICROCYSTIN YR Preparation Products And Raw materials |
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