Other grades of this product :
| CALYCULIN A Basic information |
| Product Name: | CALYCULIN A | | Synonyms: | C05370;N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide;CALYCULIN A;CALYCULIN A, DISCODERMIA CALYX;calyculin A from discodermia calyx;CALYCULIN A FROM DISCODERMIA CALYX, 10 U G;N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam;N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-Methoxy-4,6,8,9,13-pentaMethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-triMethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o | | CAS: | 101932-71-2 | | MF: | C50H81N4O15P | | MW: | 1009.17 | | EINECS: | | Product Categories: | Kinase/Phosphatase Biology;Serine/Threonine Kinase Biology;Protein phosphatase-1, Catalytic SubunitCancer Research;Tumor Promotors;Cell Signaling and Neuroscience;P to;Serine/Threonine Phosphatase Substrates;Phosphatase InhibitorsSerine/Threonine Kinase Biology;Protein Phosphatase 1 (PP1)Enzyme Inhibitors by Enzyme;Serine/Threonine Phosphatase Inhibitors;Tumor Growth Regulation;Inhibitor | | Mol File: | 101932-71-2.mol |
| CALYCULIN A Chemical Properties |
| Melting point | 247-249° | | alpha | D -60° (c = 0.1 in ethanol) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble | | form | solid | | pka | 1.81±0.10(Predicted) | | color | white | | Water Solubility | Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water. | | Merck | 13,1731 | | BRN | 4903216 |
| Hazard Codes | T | | Risk Statements | 23/24/25-38 | | Safety Statements | 36/37/39-45 | | RIDADR | UN 3462 6.1/PG 3 | | WGK Germany | 3 | | F | 8-10 | | HazardClass | 6.1(a) | | PackingGroup | II | | HS Code | 2934999090 |
| CALYCULIN A Usage And Synthesis |
| Uses | Inhibitor of phosphatases 1 and 2a. | | Uses | Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer. | | Uses | Calyculin A from Discodermia calyx has been used:- as an inhibitor of serine-threonine protein phosphatase 2A
- as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
- as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells
| | General Description | Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da. | | Biological Activity | Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C. | | Biochem/physiol Actions | Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor. |
| CALYCULIN A Preparation Products And Raw materials |
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