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| Malonamide Basic information |
| Malonamide Chemical Properties |
| Melting point | 172-175 °C (lit.) | | Boiling point | 191.38°C (rough estimate) | | density | 1.3516 (rough estimate) | | refractive index | 1.5110 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in HCl. | | form | powder to crystal | | pka | 7.00±0.70(Predicted) | | color | White to Almost white | | Water Solubility | 180 g/L (20 ºC) | | BRN | 1751401 | | CAS DataBase Reference | 108-13-4(CAS DataBase Reference) | | NIST Chemistry Reference | Propanediamide(108-13-4) | | EPA Substance Registry System | Propanediamide (108-13-4) |
| Safety Statements | 22-24/25 | | WGK Germany | 2 | | RTECS | ON9125000 | | TSCA | Yes | | HS Code | 29241900 |
| Malonamide Usage And Synthesis |
| Description | Malonamide is a dicarboxylic acid diamide that is malonic acid in which both carboxy groups have been replaced by carbamoyl groups. It is functionally related to a malonic acid. | | Chemical Properties | White crystalline powder | | Uses | Malonamide is used in the synthesis of malonamic acid, malonamate and malonamide derivative of some heterocyclic compounds with antiinflammatory activity. | | Uses | Malonamide is a reagent for fluorimetric determination of reducing carbohydrates. The malonamide-based ionic liquid extractant was used in the extraction of europium(iii) and other trivalent rare earth elements from nitric acid medium. | | Uses | The malonamide-based ionic liquid extractant was used in the
extraction of europium(iii) and other trivalent rare-earth ions from
nitric acid medium. | | General Description | The malonamide derivatives are obtained by the one-pot, five-component condensation reaction of isocyanide, Meldrum′s acid, arylidene malononitrile, and two amine molecules in CH2Cl2. | | Hazard | Mildly toxic by ingestion. | | Synthesis | The synthesis of Malonamide is as follows:A typical reaction was carried out in a 10 mL flask. Benzonitrile (2 mmol), CuII-4 ? (0.2 g), acetaldoxime (6 mmol) and MeOH (4 mL) were stirred at 65 °C for 4 h. The solid was filtered, washed with MeOH and the filtrate evaporated. The residue was subjected to GC-MS analysis and NMR spectroscopy. The filtered catalyst can be recycled after drying at about 150 °C for 1 h. | | Purification Methods | Crystallise the amide from water. [Beilstein 2 IV 1887.] |
| Malonamide Preparation Products And Raw materials |
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