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| DEVAZEPIDE Basic information |
| Product Name: | DEVAZEPIDE | | Synonyms: | N-[(3S)-2,3-DIHYDRO-1-METHYL-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-1H-INDOLE-2-CARBOXAMIDE;DEVAZEPIDE;EVAZEPIDE, PANOS;(3S)-1-Methyl-3-[(1H-indol-2-yl)carbonylamino]-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one;L-364718;MK-329;(S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide;1H-Indole-2-carboxamide, N-[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]- | | CAS: | 103420-77-5 | | MF: | C25H20N4O2 | | MW: | 408.45 | | EINECS: | | Product Categories: | | Mol File: | 103420-77-5.mol |
| DEVAZEPIDE Chemical Properties |
| Boiling point | 758.6±60.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >5mg/mL | | pka | 13.25±0.40(Predicted) | | form | powder | | color | white to off-white |
| Hazard Codes | T+ | | Risk Statements | 28 | | Safety Statements | 28-36/37-45 | | RIDADR | UN 2811 6.1 / PGI | | WGK Germany | 3 | | RTECS | NL5994460 |
| DEVAZEPIDE Usage And Synthesis |
| Uses | Antagonist (cholecystokinin). | | Uses | Devazepide has been used as a cholecystokinin receptor 1 (CCK1R) antagonist in human embryonic kidney 293T cells and in human pancreatic slices. | | Definition | ChEBI: An indolecarboxamide obtained by formal condensation of the carboxy group of indole-2-carboxylic acid with the exocyclic amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one. A cholecystokinin antagonist used f
r treatment of gastrointestinal disorders. | | General Description | Devazepide is derived from asperlicin by chemical modification and has the benzodiazepine backbone. | | Biochem/physiol Actions | Devazepide is a CCK1 (CCK-A) receptor antagonist and a CCK8 antagonist. |
| DEVAZEPIDE Preparation Products And Raw materials |
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