CTOP

CTOP
  • CAS No.:103429-31-8
Other grades of this product :
CTOP Basic information
Product Name:CTOP
Synonyms:threoninamide;NALTRIBEN;NTB;D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR AMIDE;D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2;DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL;CTOP;CYS2,TYR3,ORN5,PEN7-AMIDE
CAS:103429-31-8
MF:C50H67N11O11S2
MW:1062.26
EINECS:
Product Categories:peptide;Neuropeptides;Opioid Peptides;Other Opioid Peptides;Other Opioid PeptidesPeptides for Cell Biology;Opioid receptor and opioid-like receptor
Mol File:103429-31-8.mol
CTOP Chemical Properties
Boiling point 1491.2±65.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
RTECS XO8578200
storage temp. -20°C
pka9.90±0.15(Predicted)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
CTOP Usage And Synthesis
UsesCTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.
UsesCTOP has been used:
  • to study the anxiogenic effects induced by CTOP in mice and rat.
  • to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
  • to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).
General DescriptionD-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.
Biochem/physiol ActionsSelective ligand for μ-opioid receptors.
CTOP Preparation Products And Raw materials

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