4-(4-Methoxyphenyl)-2-butanone

CAS No.：104-20-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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4-(4-Methoxyphenyl)-2-butanone Basic information

Product Name:	4-(4-Methoxyphenyl)-2-butanone
Synonyms:	2-Butanone, 4-(p-methoxyphenyl)-;4-(4-;4-(4-methoxyphenyl)-2-butanon;4-(4-methoxyphenyl)butan-2;4-(P-METHOXYPHENYL)-2-BUTANONE 98+% F&;2-Butanone, 4-(4-methoxyphenyl)-;P-METHOXY PHENYL BUTANONE;PARA ANISYL ACETONE
CAS:	104-20-1
MF:	C11H14O2
MW:	178.23
EINECS:	203-184-2
Product Categories:	Miscellaneous;ketone;Aromatic Ketones (substituted)
Mol File:	104-20-1.mol

4-(4-Methoxyphenyl)-2-butanone Chemical Properties

Melting point	8 °C (lit.)
Boiling point	152-153 °C/15 mmHg (lit.)
density	1.046 g/mL at 25 °C (lit.)
vapor pressure	9-2000Pa at 20-115℃
FEMA	2672 \| 4-(P-METHOXYPHENYL)-2-BUTANONE
refractive index	n20/D 1.519(lit.)
Fp	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	A colourless oily liquid with a sweet floral odour
Water Solubility	Not miscible in water.
JECFA Number	818
BRN	1869592
LogP	2 at 23.1℃
CAS DataBase Reference	104-20-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Butanone, 4-(4-methoxyphenyl)-(104-20-1)
EPA Substance Registry System	2-Butanone, 4-(4-methoxyphenyl)- (104-20-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	23-24/25
WGK Germany	2
RTECS	EL9085500
TSCA	Yes
HS Code	29145090
toxicity	Both the acute oral LD₅₀ value in rats and the acute dermal LD₅₀ value in rabbits exceeded 5 g/kg (Russell, 1973)

MSDS Information

Provider	Language
Anisylacetone	English
ACROS	English
SigmaAldrich	English
ALFA	English

4-(4-Methoxyphenyl)-2-butanone Usage And Synthesis

Description	4-(p-Methoxyphenyl)-2-butanone has an intensely sweet, floral, fruity odor and a cherry-raspberry flavor at low concentrations. May be prepared by condensing acetone with anisaldehyde to yield anisylidene acetone and subsequent hydrogenation in the presence of Pd catalyst.
Chemical Properties	4-(p-Methoxyphenyl)-2-butanone has an intensely sweet, floral,fruity odor and cherry–raspberry flavor at low concentrations.
Chemical Properties	clear colourless to pale yellow liquid
Occurrence	Contained (approximately 53% level) in the odorous principle obtained by extraction and hydrolysis from aloe wood (Aquilaria algallocha Roxb.) and in anise.
Uses	4-(4-Methoxyphenyl)-2-butanone is used as pharmaceutical intermediate.
Uses	In insect attractants, organic synthesis, flavoring.
Preparation	By condensing acetone with anisaldehyde to yield anisylidene acetone and subsequent hydrogenation in the presence of Pd catalyst.
Aroma threshold values	Aroma characteristics at 5.0%: sweet, fruity, woody, powdery, honey, vanilla, raspberry and ionone-like.
Taste threshold values	Taste characteristics at 40 ppm: floral, woody, ionone, raspberry, fruity, spice and berry.
Synthesis Reference(s)	Tetrahedron Letters, 33, p. 951, 1992 DOI: 10.1016/S0040-4039(00)91585-5
Safety Profile	Low oral and skin toxicity. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

4-(4-Methoxyphenyl)-2-butanone Preparation Products And Raw materials

Raw materials

7-Methoxy-2-tetralone

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