Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride

CAS No.：1049741-81-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride Basic information

Product Name:	Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride
Synonyms:	Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride
CAS:	1049741-81-2
MF:	C16H19ClN2O2
MW:	306.78726
EINECS:
Product Categories:
Mol File:	1049741-81-2.mol

Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride Chemical Properties

storage temp.	2-8°C
solubility	DMSO: soluble30mg/mL
form	solid
color	off-white

Safety Information

Hazard Codes	Xn
Risk Statements	22
WGK Germany	3

MSDS Information

Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride Usage And Synthesis

Uses

Ciproxifan Hydrochloride is a novel chemical series of human histamine H3-receptor antagonists.

Biochem/physiol Actions

Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride Preparation Products And Raw materials

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