N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

CAS No.：1052147-86-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Basic information

Product Name:	N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
Synonyms:	LP-211;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;LP-211; LP 211; LP211;1052147-86-0;LP21;LP-211 >=98% (HPLC)
CAS:	1052147-86-0
MF:	C30H34N4O
MW:	466.62
EINECS:
Product Categories:	API
Mol File:	1052147-86-0.mol

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Chemical Properties

storage temp.	2-8°C
form	solid
color	clear white to light brown

Safety Information

MSDS Information

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Usage And Synthesis

Uses

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity.

Biochem/physiol Actions

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Preparation Products And Raw materials

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