Other grades of this product :
| CGP 20712 A Basic information |
| Product Name: | CGP 20712 A | | Synonyms: | CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE;1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd;CGP207122HCl;CGP-20712A methanesulfonate salt;(±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt;1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE;CGP 20712 DIHYDROCHLORIDE;(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate | | CAS: | 105737-62-0 | | MF: | C23H25F3N4O5.CH4O3S | | MW: | 590.57 | | EINECS: | | Product Categories: | Adrenoceptor | | Mol File: | 105737-62-0.mol |
| CGP 20712 A Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: 10 mg/mL | | form | solid | | color | white |
| CGP 20712 A Usage And Synthesis |
| Uses | CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles. | | Biological Activity | Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ . | | Biochem/physiol Actions | CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist. | | in vitro | In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors. | | in vivo | Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection. |
| CGP 20712 A Preparation Products And Raw materials |
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