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| (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Basic information |
| Product Name: | (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol | | Synonyms: | (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride;(2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride;(2S,3S)-Hydroxybupropion hydrochloride;GW 353162;SS-hydroxybupropion hydrochloride;(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol;Bupropion Morpholinol (2S,3S)-Isomer;Bupropion Morpholinol IMpurity | | CAS: | 106083-71-0 | | MF: | C13H18ClNO2 | | MW: | 255.74052 | | EINECS: | | Product Categories: | | Mol File: | 106083-71-0.mol |
| (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: ≥12mg/mL | | form | powder | | color | white to tan |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | WGK Germany | 3 |
| (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Usage And Synthesis |
| Uses | Antidepressant; antianxiety. | | General Description | (2S,3S)-hydroxybupropion is a major metabolite of bupropion. | | Biochem/physiol Actions | (2S,3S)-hydroxybupropion is a dopamine transporter (DAT) and norepinephrine transporter (NET) transporters inhibitor and nicotinic acetylcholine receptor (nAChR) family modulator. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in nicotine-dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of nicotine reward in mice. |
| (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol Preparation Products And Raw materials |
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