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| TAFENOQUINE SUCCINATE Basic information |
| Product Name: | TAFENOQUINE SUCCINATE | | Synonyms: | WR-238605;Butanedioic acid, compd. with N(sup 4)-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine (1:1);Wr238605 succinate;Tafenoquine Succinate;N-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine;SB-252263;Krintafel;TAFENOQUINE SUCCINATE; WR-238605, WR 238605, WR238605, SB-252263-AAB; SB252263-AAB; SB 252263-AAB; KRINTAFEL; | | CAS: | 106635-81-8 | | MF: | C28H34F3N3O7 | | MW: | 581.5806696 | | EINECS: | | Product Categories: | | Mol File: | 106635-81-8.mol |
| TAFENOQUINE SUCCINATE Chemical Properties |
| Melting point | 146-149° | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL (clear solution) | | form | powder | | color | white to beige |
| WGK Germany | 3 | | Toxicity | LD50 in male, female rats (mg/kg): 102, 71 i.p.; 429, 416 orally (LaMontagne) |
| TAFENOQUINE SUCCINATE Usage And Synthesis |
| Uses | Tafenoquine succinate is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the preven tion and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
| | Uses | Tatenoquine is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase. | | Biochem/physiol Actions | Tafenoquine is an antimalarial primaquine analog being investigated to treat and prevent Plasmodium vivax infections. It can eliminate both blood and liver stages of Plasmodium vivax. Tafenoquine has also been tested as a therapy for leishmaniasis. |
| TAFENOQUINE SUCCINATE Preparation Products And Raw materials |
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