Product

Rho Kinase Inhibitor V

CAS No.：1072906-02-5

Other grades of this product :

Rho Kinase Inhibitor V Basic information

Product Name:	Rho Kinase Inhibitor V
Synonyms:	Rho Kinase Inhibitor V;Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem
CAS:	1072906-02-5
MF:	C18H15N3O3
MW:	321.33
EINECS:
Product Categories:
Mol File:	1072906-02-5.mol

Rho Kinase Inhibitor V Chemical Properties

storage temp.	+2C to +8C
form	Light beige solid

Safety Information

MSDS Information

Rho Kinase Inhibitor V Usage And Synthesis

General Description

A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC₅₀ = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC₅₀ = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC₅₀ = 0.186, 1.19, and 1.41 μM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 μM = 87/40/1/20, respectively) only at much higher concentrations.

Rho Kinase Inhibitor V Preparation Products And Raw materials

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873