Rho Kinase Inhibitor V

CAS No.：1072906-02-5

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Rho Kinase Inhibitor V Basic information

Product Name:	Rho Kinase Inhibitor V
Synonyms:	Rho Kinase Inhibitor V;Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem
CAS:	1072906-02-5
MF:	C18H15N3O3
MW:	321.33
EINECS:
Product Categories:
Mol File:	1072906-02-5.mol

Rho Kinase Inhibitor V Chemical Properties

storage temp.	+2C to +8C
form	Light beige solid

Safety Information

MSDS Information

Rho Kinase Inhibitor V Usage And Synthesis

General Description

A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC₅₀ = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC₅₀ = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC₅₀ = 0.186, 1.19, and 1.41 μM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 μM = 87/40/1/20, respectively) only at much higher concentrations.

Rho Kinase Inhibitor V Preparation Products And Raw materials

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