Other grades of this product :
| Product Name: | NERI02 | | Synonyms: | 4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol trihydrochloride;F06;NERI02;NSC130813;NSC130813 >=98% (HPLC);HM03 trihydrochloride | | CAS: | 1082532-95-3 | | MF: | C26H28Cl2N4O2 | | MW: | 499.44 | | EINECS: | | Product Categories: | | Mol File: | 1082532-95-3.mol |
| NERI02 Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble10mg/mL, clear | | form | powder | | color | yellow to orange |
| NERI02 Usage And Synthesis |
| Biochem/physiol Actions | NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C. |
| NERI02 Preparation Products And Raw materials |
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