Other grades of this product :
| Product Name: | FIN56 | | Synonyms: | FIN56;FIN-56;FIN 56;FIN56;FIN-56 ;FIN 56;N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide;9H-Fluorene-2,7-disulfonamide, N2,N7-dicyclohexyl-9-(hydroxyimino)-;FIN56 >=98% (HPLC);FIN56 N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide | | CAS: | 1083162-61-1 | | MF: | C25H31N3O5S2 | | MW: | 517.66 | | EINECS: | | Product Categories: | | Mol File: | 1083162-61-1.mol |
| FIN56 Chemical Properties |
| Boiling point | 759.1±70.0 °C(Predicted) | | density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | room temp | | solubility | Soluble in DMSO (>25 mg/ml) | | form | powder | | pka | 10.10±0.20(Predicted) | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| FIN56 Usage And Synthesis |
| Description | FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1? FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2 | | Biochem/physiol Actions | Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers. | | References | Shimada et al. (2016), Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis; Chem. Biol. 12 497
Zhang et al. (2021), FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma; Cancer 12 6610 |
| FIN56 Preparation Products And Raw materials |
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