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| H-7 DIHYDROCHLORIDE Basic information |
| Product Name: | H-7 DIHYDROCHLORIDE | | Synonyms: | H-7 DIHYDROCHLORIDE;H-7;(+/-)-1-(5-ISOQUINOLINESULPHONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE;1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE;(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL;1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL;(-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, DI-HCL SALT;(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE | | CAS: | 108930-17-2 | | MF: | C14H19Cl2N3O2S | | MW: | 364.29 | | EINECS: | | Product Categories: | Protein Kinase Inhibitors and Activators | | Mol File: | 108930-17-2.mol |
| H-7 DIHYDROCHLORIDE Chemical Properties |
| Melting point | 215-225 °C | | storage temp. | 2-8°C | | solubility | H2O: 20 mg/mL | | form | Light yellow lyophilized solid | | color | White to Off-White | | BRN | 5840763 | | CAS DataBase Reference | 108930-17-2(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | F | 10 |
| H-7 DIHYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White Crystalline Solid | | Uses | A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases | | Uses | H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor. | | Definition | ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride. | | General Description | A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells. | | Biochem/physiol Actions | Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively |
| H-7 DIHYDROCHLORIDE Preparation Products And Raw materials |
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