| 2-Methylpiperidine Basic information |
| Product Name: | 2-Methylpiperidine |
| Synonyms: | 2-PIPECOLINE 99.5%;2-PIPECOLINE 2-METHYL PIPERIDINE;α-Pipecoline, 2-Pipecoline;DL-2-Methylpiperidine;2-METHYL-PERIDINE;2-Methylpiperidine, 99% 100ML;2-Methylpiperidine, 99% 5ML;D-A-PIPECOLINE |
| CAS: | 109-05-7 |
| MF: | C6H13N |
| MW: | 99.17 |
| EINECS: | 203-642-1 |
| Product Categories: | Building Blocks;C5 to C7;Piperidine;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines |
| Mol File: | 109-05-7.mol |
| 2-Methylpiperidine Chemical Properties |
| Melting point | -4--5 °C |
| Boiling point | 118-119 °C/753 mmHg (lit.) |
| density | 0.844 g/mL at 25 °C (lit.) |
| FEMA | 4244 | 2-METHYLPIPERIDINE |
| refractive index | n |
| Fp | 47 °F |
| storage temp. | Flammables area |
| form | Liquid |
| pka | pK1:10.95(+1) (25°C) |
| color | Clear yellow |
| PH | 12-13 (111g/l, H2O) |
| Water Solubility | soluble |
| JECFA Number | 1608 |
| BRN | 79804 |
| CAS DataBase Reference | 109-05-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Methylpiperidine(109-05-7) |
| EPA Substance Registry System | Piperidine, 2-methyl- (109-05-7) |
| Safety Information |
| Hazard Codes | F,Xn |
| Risk Statements | 11-36/37/38-34-22-41-37/38 |
| Safety Statements | 16-26-39-45-36/37/39 |
| RIDADR | UN 1993 3/PG 2 |
| WGK Germany | 3 |
| RTECS | TN1240000 |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29333999 |
| MSDS Information |
| Provider | Language |
|---|---|
| 2-Pipecoline | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 2-Methylpiperidine Usage And Synthesis |
| Chemical Properties | Colorless to yellow liquid; pepper-like aroma. |
| Chemical Properties | CLEAR YELLOW LIQUID |
| Uses | Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation1Reactant for synthesis of:• ;Azepan-4-ones via two step [5+2] annulation2• ;2-Aminobenzoxazoles3• ;Unsymmetrically substituted ureas4• ;Corticotropin-releasing factor receptor type 1 antagonists5• ;Gefitinib analogues with anti-tumor activity6 |
| Uses | 2-Methylpiperidine, is used for the oxidation of secondary amines to nitrones by means of H2O2 catalyzed by Sodium tungsten oxide dihydrate. |
| Aroma threshold values | High strength; ammoniacal type; recommend smelling in a 1.0% solution or less. |
| Taste threshold values | Amine, creamy, taco, lettuce taste at 5 ppm in water. |
| Synthesis Reference(s) | Journal of the American Chemical Society, 111, p. 4108, 1989 DOI: 10.1021/ja00193a056 |
| 2-Methylpiperidine Preparation Products And Raw materials |
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