Other grades of this product :
| Rac1 Inhibitor II Basic information |
| Product Name: | Rac1 Inhibitor II | | Synonyms: | Rac1 Inhibitor II;Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem;InSolution Rac1 Inhibitor II, Z62954982 - CAS 1090893-12-1 - Calbiochem;Benzamide, N-[3-(aminosulfonyl)-4-methylphenyl]-3-[(3,5-dimethyl-4-isoxazolyl)methoxy]-;Z62954982 (Synonyms: ZINC08010136) | | CAS: | 1090893-12-1 | | MF: | C20H21N3O5S | | MW: | 415.46 | | EINECS: | | Product Categories: | | Mol File: | 1090893-12-1.mol |
| Rac1 Inhibitor II Chemical Properties |
| storage temp. | -20C | | form | Off-white solid |
| Rac1 Inhibitor II Usage And Synthesis |
| General Description | A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 μM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 μM). Also available in InSolution format (Cat. No. 553512). |
| Rac1 Inhibitor II Preparation Products And Raw materials |
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