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| ALPHA-ACTININ Basic information |
| ALPHA-ACTININ Chemical Properties |
| storage temp. | 2-8°C | | form | ammonium sulfate suspension |
| WGK Germany | 3 | | HS Code | 3504009000 |
| ALPHA-ACTININ Usage And Synthesis |
| Uses | α-Actinin from chicken gizzard has been used: - as an antigen to coat plates for the capture of anti-actinin antibody using enzyme-linked immunosorbent assay (ELISA) from tumor cell line clones
- in in vitro motility experiments to test its effect on actin filament movement
- to coat cantilevers for strengthening fluorescently labeled actin filaments in force measurement studies
| | General Description | α-Actinin exists as a rod-shaped antiparallel dimer with two elongated subunits. The domain region contains an N-terminal actin-binding domain with tandem calponin homology domains, a central tandem 3-helix motifs, and EF-hand motifs at C-terminus. It belongs to the spectrin superfamily and is localized in actin structures. | | Biochem/physiol Actions | α-Actinin binds actin and has the ability to crosslink actin cytoskeleton. It also plays a key role in the structural maintenance of the Z-disk of striated muscle. |
| ALPHA-ACTININ Preparation Products And Raw materials |
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