Diglycolic acid

CAS No.：110-99-6

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Diglycolic acid Basic information

Product Name:	Diglycolic acid
Synonyms:	2,2’-oxybis-aceticaci;2,2’-oxybisaceticacid;2,2’-oxybis-Aceticacid;3-Oxapentanedioic acid;3-oxapentanedioicacid;Acetic acid, 2,2'-oxybis-;Acetic acid,oxydi;alpha,alpha-Oxydiacetic acid
CAS:	110-99-6
MF:	C4H6O5
MW:	134.09
EINECS:	203-823-5
Product Categories:	Heterocyclic Compounds
Mol File:	110-99-6.mol

Diglycolic acid Chemical Properties

Melting point	140-144 °C (lit.)
Boiling point	167.16°C (rough estimate)
density	1.486
refractive index	1.4000 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	ethanol: soluble5%, clear to slightly hazy, colorless to greenish-yellow
pka	pK1:2.96 (25°C)
form	Crystalline Powder
color	White to light beige
Water Solubility	Soluble
BRN	1072117
InChIKey	QEVGZEDELICMKH-UHFFFAOYSA-N
CAS DataBase Reference	110-99-6(CAS DataBase Reference)
NIST Chemistry Reference	Diglycolic acid(110-99-6)
EPA Substance Registry System	Acetic acid, 2,2'-oxybis- (110-99-6)

Safety Information

Hazard Codes	Xn,C
Risk Statements	22-36/37/38-34
Safety Statements	26-36-45-36/37/39
RIDADR	2811
WGK Germany	3
RTECS	AJ1530000
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29171900
Toxicity	LD50 orl-rat: 500 mg/kg ACIEAY 14,94,75

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

Diglycolic acid Usage And Synthesis

Chemical Properties	white to light beige crystalline powder
Uses	Diglycolic acid was used in the preparation of needle-like aragonite particles from calcium nitrate aqueous solutions.
General Description	Diglycolic acid is a toxic metabolite of diethylene glycol (DEG) responsible for DEG-induced proximal tubular necrosis.
Biochem/physiol Actions	Diglycolic acid has antithrombogenic properties and induces vasodilation. It inhibits succinate dehydrogenase activity in human proximal tubule cells.
Safety Profile	Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
Purification Methods	Crystallise diglycolic acid from water. [Beilstein 3 IV 577.]

Diglycolic acid Preparation Products And Raw materials

Raw materials	3,6-DIOXAOCTANEDIOIC ACID-->3,6,9-TRIOXAUNDECANEDIOIC ACID-->Bis[2-(2-hydroxyethoxy)ethyl] ether
Preparation Products	KRYPTOFIX(R) 221-->BIS(2,2,2-TRIFLUOROETHYL) ETHER-->MORPHOLINE-3 5-DIONE 97-->dimethyl 2,2'-thiobisacetate

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