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| 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Basic information |
| Product Name: | 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE | | Synonyms: | REMACEMIDE HYDROCHLORIDE;2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE;RemacemideHCl;2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride;2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid;2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-;fpl12924aa;pr934-423a | | CAS: | 111686-79-4 | | MF: | C17H21ClN2O | | MW: | 304.82 | | EINECS: | | Product Categories: | | Mol File: | 111686-79-4.mol |
| 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Chemical Properties |
| Melting point | 253-254° | | storage temp. | room temp | | solubility | H2O: >10mg/mL | | form | powder | | color | white to beige |
| Hazard Codes | Xn,N | | Risk Statements | 22-41-50/53 | | Safety Statements | 26-39-45-60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | RTECS | AB4349500 | | Toxicity | LD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer) |
| 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Usage And Synthesis |
| Uses | Anticonvulsant (neuroprotective). | | Biological Activity | Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC 50 = 8-68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na + channels (IC 50 = 161 mM). | | Biochem/physiol Actions | Remacemide HCl is a low affinity NMDA antagonist with anticonvulsant properties. Remacemide also been shown to block voltage-dependent sodium channels. |
| 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Preparation Products And Raw materials |
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