Product

trans-3,4-Difluorocinnamic acid

CAS No.：112897-97-9

Other grades of this product :

trans-3,4-Difluorocinnamic acid Basic information

Product Name:	trans-3,4-Difluorocinnamic acid
Synonyms:	(E)-3,4-Difluorophenylacrylic acid, (2E)-3-(3,4-Difluorophenyl)prop-2-enoic acid;3,4-DIFLUOROCINNAMIC ACID;AKOS 92715;TIMTEC-BB SBB006677;RARECHEM BK HW 0122;TRANS-3,4-DIFLUOROCINNAMIC ACID;trans-3,4-Difluorocinnamic acid 97%;trans-3,4-Difluorocinnamicacid97%
CAS:	112897-97-9
MF:	C9H6F2O2
MW:	184.14
EINECS:
Product Categories:	Aromatic Cinnamic Acids, Esters and Derivatives;Cinnamic acid;Miscellaneous;C9;Carbonyl Compounds;Carboxylic Acids;Fluoro-contained cinnamic acid series
Mol File:	112897-97-9.mol

trans-3,4-Difluorocinnamic acid Chemical Properties

Melting point	194-196 °C(lit.)
Boiling point	281.3±25.0 °C(Predicted)
density	1.3056 (estimate)
storage temp.	2-8°C
solubility	soluble in Methanol
form	powder to crystal
pka	4.27±0.10(Predicted)
color	White to Almost white
BRN	7370322
CAS DataBase Reference	112897-97-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29163990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

trans-3,4-Difluorocinnamic acid Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	trans-3,4-Difluorocinnamic Acid is a starting material in the preparation of Ticagrelor (T437700), which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel.

trans-3,4-Difluorocinnamic acid Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Ethyl acetate-->Diethyl ether-->Dichloromethane-->Magnesium sulfate-->Sodium bicarbonate-->Hexane-->Triphenylphosphine-->tert-Butyl bromoacetate-->Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester-->3,4-Difluorobenzaldehyde
Preparation Products	(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

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