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| 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Basic information |
| 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Chemical Properties |
| density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | pka | 12.12±0.46(Predicted) | | form | solid | | color | white to off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Usage And Synthesis |
| Description | PNU 75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50?= 450 nM) between β-catenin and T cell factor 4 (Tcf4). | | Uses | PNU 74654 is a β-catenin inhibitor which inhibits interactions between β-catenin and transcription factor T-cell factor 4 (Tcf4) thus disrupting the Wnt signal transduction pathway. | | Uses | PNU-74654 has been used:- as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos
- as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines
- as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells
| | Biochem/physiol Actions | PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF. | | References | 1) Trosset?et al. (2006)?Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening; Proteins,?64?60 |
| 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Preparation Products And Raw materials |
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![2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide](/img/113906-27-7.jpg "2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide")
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