Product

Tubulin Polymerization Inhibitor II

CAS No.：1151995-69-5

Other grades of this product :

Tubulin Polymerization Inhibitor II Basic information

Product Name:	Tubulin Polymerization Inhibitor II
Synonyms:	Tubulin Polymerization Inhibitor II;2H-Indol-2-one, 1,3-dihydro-6-methoxy-3-[(3,4,5-trimethoxyphenyl)methylene]-
CAS:	1151995-69-5
MF:	C19H19NO5
MW:	341.36
EINECS:
Product Categories:	Angiogenesis and Metastasis;Growth Factors and Cytokines
Mol File:	1151995-69-5.mol

Tubulin Polymerization Inhibitor II Chemical Properties

Boiling point	549.5±50.0 °C(Predicted)
density	1.241±0.06 g/cm3(Predicted)
storage temp.	+2C to +8C
form	Yellow solid
pka	12.16±0.20(Predicted)

Safety Information

MSDS Information

Tubulin Polymerization Inhibitor II Usage And Synthesis

Uses	Tubulin Polymerization Inhibitor II is a Tubulin inhibitor.
General Description	A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC₅₀ = 4.5 μM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI₅₀<10 nM for 46 lines among a 53 NCI panel tested).
Biochem/physiol Actions	Cell permeable: yes

Tubulin Polymerization Inhibitor II Preparation Products And Raw materials

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