Other grades of this product :
| Melting point | 202-205 °C(lit.) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly) | | pka | 8.67±0.46(Predicted) | | form | Off-white to yellow solid. | | color | Pale Yellow to Green | | Stability: | Unstable in methanol | | CAS DataBase Reference | 1154-25-2 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | RIDADR | 2811 | | WGK Germany | 3 | | HazardClass | 6.1(b) | | PackingGroup | III |
| Description | Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively. It less effectively inhibits NHE4 (IC50 ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity. | | Chemical Properties | Yellow Solid | | Uses | Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions. | | Uses | 5-(N-Ethyl-N-isopropyl)amiloride has been used:- as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
- in Pluronic F-127 stock solution for Drosophila larval live-imaging
- in choline chloride solution as an experimental perfusate, to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo
| | Uses | Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions | | Biochem/physiol Actions | Selective blocker of Na+/H+ antiport |
| EIPA Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye