6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS)

6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS)
  • CAS No.:115853-74-2
Other grades of this product :
6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS) Basic information
Product Name:6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS)
Synonyms:2',6'-DiMethyl-4'-(N-succiniMidyloxycarbonyl)phenyl-10-Methyl-acridiniuM-9-carboxylate Methosulfate;Alkyne-PEG5-NHS ester;Acetylene-PEG5-NHS ester;Alkyne-PEG5-N-hydroxysuccinimidyl ester;Alkyne-PEG5-succinimidyl ester;6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS);DMAE-NHS;2',6'-DiMethylcarbonylphenyl 10-Methyl-9-acridinecarboxylate 4'-NHS Ester Methylsulfate
CAS:115853-74-2
MF:C29H26N2O10S
MW:594.58914
EINECS:
Product Categories:Aromatics;Heterocycles;Labeling and Diagnostics Reagents;Sulfur & Selenium Compounds
Mol File:115853-74-2.mol
6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS) Chemical Properties
Melting point 228-230℃
storage temp. -20°C
Safety Information
MSDS Information
6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS) Usage And Synthesis
UsesNovel acridinium esters are disclosed that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays.
UsesHeterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.
6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS) Preparation Products And Raw materials
Raw materials2',6'-DiMethylcarbonylphenyl 9-Acridinecarboxylate 4'-NHS Ester-->4-Hydroxy-3,5-dimethylbenzoic acid-->Dimethyl sulfate

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