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| CHOLIC-2,2,4,4-D4 ACID Basic information |
| Product Name: | CHOLIC-2,2,4,4-D4 ACID | | Synonyms: | Cholic-d4 Acid;Cholic acid-2,2,4,4-d;5β-cholanic acid-3α,7α,12α-triol-2,2,4,4-d4;CHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL;Cholic Acid -[d4] (Solution);Cholic Acid-d4 MaxSpec? Standard | | CAS: | 116380-66-6 | | MF: | C24H36D4O5 | | MW: | 412.6 | | EINECS: | | Product Categories: | Steroids & Hormones - 13C & 2H | | Mol File: | 116380-66-6.mol |
| CHOLIC-2,2,4,4-D4 ACID Chemical Properties |
| Melting point | 200-201°C (lit.) |
| CHOLIC-2,2,4,4-D4 ACID Usage And Synthesis |
| Description | Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid by GC- or LC-MS. Cholic acid is a primary bile acid. It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; ) and taurocholic acid (TCA; ), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; ) by intestinal microbiota. It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v. Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats. | | Uses | Cholic Acid-d4 is a labelled analog of Cholic acid (C432600) which is a choleretic produced by, and isolated from liver cells. |
| CHOLIC-2,2,4,4-D4 ACID Preparation Products And Raw materials |
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