Other grades of this product :
| BRL 44408 MALEATE Basic information |
| Product Name: | BRL 44408 MALEATE | | Synonyms: | 2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE;2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE;BRL 44408 MALEATE;2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole;Alendronate sodium trihydrate,4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217;2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole;BRL 44408;2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt | | CAS: | 118343-19-4 | | MF: | C13H17N3 | | MW: | 215.29 | | EINECS: | | Product Categories: | Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Adrenoceptor | | Mol File: | 118343-19-4.mol |
| BRL 44408 MALEATE Chemical Properties |
| Boiling point | 365.8±30.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | H2O: ~26 mg/mL, soluble | | form | solid | | pka | 10.29±0.40(Predicted) | | color | off-white |
| BRL 44408 MALEATE Usage And Synthesis |
| Uses | Selective a2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration | | Uses | Selective α2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration. | | Uses | BRL 44408 Maleate was used to study for norepinephrine reuptake modulators for preventing and treating vasomotor symptoms. | | Biological Activity | Selective α 2A -adrenoceptor antagonist (K i = 1.7 nM and 144.5 nM at α 2A and α 2B -adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α 2 -Adrenoceptor Tocriset™ . | | Biochem/physiol Actions | BRL 44408 maleate is a selective α2A-adrenoceptor antagonist. | | references | [1]. meana jj, callado lf, pazos a, et al. the subtype-selective alpha 2-adrenoceptor antagonists brl 44408 and arc 239 also recognize 5-ht1a receptors in the rat brain. eur j pharmacol, 1996, 312(3): 385-388.[2]. owesson ca, seif i, mclaughlin dp, et al. different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-a knockout mice. eur j neurosci, 2003, 18(1): 34-42.[3]. dwyer jm, platt bj, rizzo sj, et al. preclinical characterization of brl 44408: antidepressant- and analgesic-like activity through selective alpha2a-adrenoceptor antagonism. int j neuropsychopharmacol, 2010, 13(9): 1193-1205. |
| BRL 44408 MALEATE Preparation Products And Raw materials |
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