(S)-2-(Methoxydiphenylmethyl)pyrrolidine

CAS No.：118971-03-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(S)-2-(Methoxydiphenylmethyl)pyrrolidine Basic information

Product Name:	(S)-2-(Methoxydiphenylmethyl)pyrrolidine
Synonyms:	(S)-2-(Methoxydiphenylmethyl)pyrrolidine;(S)-2-(MethoxydiphenylMethyl)pyrrolidine 95% (HPLC);(2S)-2-[Diphenyl(methoxy)methyl]pyrrolidine;(2S)-2-[Diphenyl(methoxy)methyl]tetrahydropyrrole;-2-(Methoxydiphenylmethyl);(2S)-2-(Methoxydiphenylmethyl)pyrrolidine;Pyrrolidine, 2-(methoxydiphenylmethyl)-, (2S)-
CAS:	118971-03-2
MF:	C18H21NO
MW:	267.37
EINECS:
Product Categories:	Asymmetric Synthesis;Chiral Catalysts, Ligands, and Reagents;Proline-Based Organocatalysts
Mol File:	118971-03-2.mol

(S)-2-(Methoxydiphenylmethyl)pyrrolidine Chemical Properties

Boiling point	368.7±32.0 °C(Predicted)
density	1.070±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	10.09±0.10(Predicted)

Safety Information

Hazard Codes	Xn
Risk Statements	22
WGK Germany	3

MSDS Information

(S)-2-(Methoxydiphenylmethyl)pyrrolidine Usage And Synthesis

Uses

(S)-2-(Methoxydiphenylmethyl)pyrrolidine is a diphenylprolinol methyl ether, which can be used as a catalyst to synthesize:

Enantioselective ketones via intermolecular asymmetric Michael addition of aldehydes to nonactivated enones.
Stereoselective chiral bipyrazolidin-3-one derivatives by dipolar cycloaddition reaction of azomethine imines with α, β-unsaturated aldehydes.
Enantioenriched spiro nitrogen heterocycles via asymmetric nucleophilic epoxidation of α-ylideneoxindole esters.
Optically active secondary alcohols by asymmetric addition of Et₂Zn to various aldehydes.

(S)-2-(Methoxydiphenylmethyl)pyrrolidine Preparation Products And Raw materials

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