N-METHYLSUCCINIMIDE

CAS No.：1121-07-9

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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N-METHYLSUCCINIMIDE Basic information

Product Name:	N-METHYLSUCCINIMIDE
Synonyms:	1-METHYL-2,5-PYRROLIDINEDIONE;1-methyl-5-pyrrolidinedione;1-Methyl-pyrrolidine-2,5-dione;2,5-Pyrrolidinedione,1-methyl-;N-Methylsuccinimid;Succinimide, N-methyl-;N-METHYLSUCCINIMIDE;N-Methylsuccinimide, 98%+
CAS:	1121-07-9
MF:	C5H7NO2
MW:	113.11
EINECS:	628-414-2
Product Categories:	Carbonyl Compounds;Cyclic Imides;Organic Building Blocks
Mol File:	1121-07-9.mol

N-METHYLSUCCINIMIDE Chemical Properties

Melting point	61-70 °C(lit.)
Boiling point	234-235 °C(lit.)
density	1.2416 (rough estimate)
refractive index	1.4790 (estimate)
Fp	234-235°C
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	-1.34±0.20(Predicted)
color	Off-White
Sensitive	Moisture Sensitive
BRN	110534
CAS DataBase Reference	1121-07-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38-41
Safety Statements	26-36/37
WGK Germany	2
RTECS	UY1028650

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

N-METHYLSUCCINIMIDE Usage And Synthesis

Chemical Properties	white crystals
Uses	N-Methylsuccinimide is used as a model compound to investigate the mechanism of enolization step by density-functional theory (DFT) calculations. N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in plasma and urine can be used as a biomarker of exposure to NMP
Synthesis Reference(s)	Chemical and Pharmaceutical Bulletin, 31, p. 4209, 1983 DOI: 10.1248/cpb.31.4209
General Description	N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in in plasma and urine can be used as a biomarker of exposure to NMP. Hydrogen bonded complexes between N-methylsuccinimide and phenols (pKa = 10.2 → 6) are investigated by infrared spectrometry.

N-METHYLSUCCINIMIDE Preparation Products And Raw materials

Raw materials	NA-->3-Phenyl-1H-pyrazole-->5-HYDROXY-1-METHYL-2-PYRROLIDONE-->N-Methylmaleimide-->Methylamine hydrochloride-->Methanol-->Methylamine-->1H-Isoindol-1-one, 3-hydroxy--->Iodomethane-->Dimethyl carbonate-->Maleimide
Preparation Products	4-hydroxy-N-methylbutyramide-->(+/-)-NICOTINE-->Succinimide

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